Inspired by the UNs Sustainable Development Goals, 50業子s Grand Challenges Programme launched in 2017 with an initial focus on five global challenges: climate change, global health, the foodenergywater nexus, a digitally transformed world and sustainable cities. We spoke to Mariette DiChristina, Executive Vice President of Editorial and Publishing for Nature Research Magazines and Editor-in-Chief of Scientific American, to get her insights into how the Grand Challenges Programme has grown over the past 18 months.